Dynamic hematological disease: a review

J Math Biol. 2009 Jan;58(1-2):285-322. doi: 10.1007/s00285-008-0165-3. Epub 2008 Mar 4.

Abstract

We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computer Simulation
  • Hematologic Diseases / blood*
  • Hematologic Diseases / pathology*
  • Hematopoiesis
  • Humans
  • Models, Biological*