Mutations in influenza A virus (H5N1) and possible limited spread, Turkey, 2006

Ender Altiok; Fulya Taylan; Osman S Yenen; Gülşah Demirkeser; Mürvet Bozaci; Derya Onel; Birsen Akcadag; A Selma Iyisan; Meral Ciblak; Emel Bozkaya; Sirin Yuksel; Selim Badur

doi:10.3201/eid1403.061237

Mutations in influenza A virus (H5N1) and possible limited spread, Turkey, 2006

Emerg Infect Dis. 2008 Mar;14(3):491-2. doi: 10.3201/eid1403.061237.

Authors

Ender Altiok¹, Fulya Taylan, Osman S Yenen, Gülşah Demirkeser, Mürvet Bozaci, Derya Onel, Birsen Akcadag, A Selma Iyisan, Meral Ciblak, Emel Bozkaya, Sirin Yuksel, Selim Badur

Affiliation

¹ Acibadem Genetic Diagnosis Center, Istanbul, Turkey. ealtiok@asg.com.tr

Abstract

We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey. Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.

MeSH terms

Amino Acid Sequence
Animals
Chickens / virology*
Disease Outbreaks
Humans
Influenza A Virus, H5N1 Subtype / genetics*
Influenza in Birds / epidemiology
Influenza in Birds / virology*
Influenza, Human / epidemiology
Influenza, Human / virology*
Mutation
Turkey / epidemiology