A potent anti-HIV polyphenol from Salvia yunnanensis

J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):273-7. doi: 10.1080/10286020701605075.

Abstract

A new polyphenol, designated as salvianolic acid N, was isolated from the aqueous extracts of the roots of Salvia yunnanensis. Its chemical structure was elucidated as 3-(3,4-dihydroxylphenyl)-2-[(E)-3-(1,8,9-trihydroxyl-dibenzo[b,f]oxpin-3-yl)acryloxloxy]propanoic acid (1) on the basis of NMR and MS spectral analyses. The new polyphenol inhibited both HIV-1 IN in vitro and also reduced HIV-1 p24 antigen in MT-4 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • HIV Core Protein p24 / antagonists & inhibitors
  • HIV Core Protein p24 / biosynthesis
  • HIV Integrase / metabolism
  • HIV Integrase Inhibitors / chemistry
  • HIV Integrase Inhibitors / isolation & purification
  • HIV Integrase Inhibitors / pharmacology
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV-1 / enzymology
  • HIV-1 / metabolism
  • Humans
  • Inhibitory Concentration 50
  • Nuclear Magnetic Resonance, Biomolecular
  • Optical Rotation
  • Phenols / chemistry
  • Phenols / isolation & purification*
  • Phenols / pharmacology
  • Plant Roots / chemistry
  • Polyphenols
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / isolation & purification
  • Reverse Transcriptase Inhibitors / pharmacology
  • Salvia / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Anti-HIV Agents
  • Flavonoids
  • HIV Core Protein p24
  • HIV Integrase Inhibitors
  • Phenols
  • Polyphenols
  • Reverse Transcriptase Inhibitors
  • HIV Integrase
  • HIV Reverse Transcriptase