Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa

J Enzyme Inhib Med Chem. 2008 Feb;23(1):140-3. doi: 10.1080/14756360701342532.

Abstract

Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Buddleja*
  • Iridoids / chemistry
  • Iridoids / isolation & purification
  • Iridoids / pharmacology*
  • Lipoxygenase / metabolism
  • Lipoxygenase Inhibitors / chemistry
  • Lipoxygenase Inhibitors / isolation & purification
  • Lipoxygenase Inhibitors / pharmacology*
  • Models, Molecular
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Structure-Activity Relationship

Substances

  • Antioxidants
  • Iridoids
  • Lipoxygenase Inhibitors
  • Plant Extracts
  • Lipoxygenase