Typical and atypical pulmonary carcinoids: our institutional experience

Interact Cardiovasc Thorac Surg. 2008 May;7(3):415-8. doi: 10.1510/icvts.2007.173328. Epub 2008 Mar 18.

Abstract

Pulmonary carcinoids are rare malignant neoplasms, accounting for 2-5% of all lung tumors, with an approximate annual incidence of 2.3-2.8 cases per million of the population. We relate our experience of 54 patients (21 male, 33 female, mean age 53+/-15 years) treated between July 1986 and April 2006. All the patients underwent preoperative fibrobronchoscopy: preoperative diagnosis was made in 28 patients (52%). Surgical treatment consisted of: 31 standard lobectomies, 6 pneumonectomies, 5 bilobectomies, 2 sleeve lobectomies, 2 anatomic segmentectomies, 6 wedge resections; two patients were managed with sleeve bronchial procedure of the left main bronchus without lung resection. Fifty-four patients were followed with a mean time of observation of 67 months: 6 (11%) deaths occurred, at a mean period of 49 months after surgery; there were no postoperative deaths. Overall, 5-year survival was 91%, 10 years 83%: 5-year survival was 91% for typical carcoinoids (TC) vs. 88% for atypical (AC), 10 years 91% for TC and 44% for AC (significant value, P=0.0487). Carcinoid tumors are a distinct group of neuroendocrine tumors with a good prognosis in most cases. Surgery currently represents the best treatment with good results at mid- and long-term survival, according to an acceptable risk.

MeSH terms

  • Adult
  • Aged
  • Bronchial Neoplasms* / mortality
  • Bronchial Neoplasms* / pathology
  • Bronchial Neoplasms* / surgery
  • Bronchoscopy / methods
  • Carcinoid Tumor* / mortality
  • Carcinoid Tumor* / pathology
  • Carcinoid Tumor* / surgery
  • Female
  • Fiber Optic Technology
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Pneumonectomy
  • Time Factors
  • Treatment Outcome