Chemotherapy and cancer stem cells

Cell Stem Cell. 2007 Oct 11;1(4):353-5. doi: 10.1016/j.stem.2007.09.011.

Abstract

Cancer stem cells are subsets of tumor cells defined through the capacity to initiate tumors and have been linked to therapeutic resistance. In this issue of Cell Stem Cell, Todaro et al. (2007) demonstrate that targeting tumor IL-4 sensitizes colon cancer stem cells to chemotherapy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Cell Death / drug effects
  • Colonic Neoplasms / pathology
  • Fluorouracil / pharmacology
  • Humans
  • Interleukin-4 / biosynthesis
  • Mice
  • Neoplastic Stem Cells / drug effects
  • Neoplastic Stem Cells / pathology*
  • Organoplatinum Compounds / pharmacology
  • Oxaliplatin
  • Receptors, Interleukin-4 / metabolism

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Receptors, Interleukin-4
  • Oxaliplatin
  • Interleukin-4
  • Fluorouracil