Solid-phase synthesis of tris-heteroleptic ruthenium(II) complexes and application to acetylcholinesterase inhibition

Inorg Chem. 2008 Jun 16;47(12):5030-2. doi: 10.1021/ic800080b. Epub 2008 Mar 29.

Abstract

A synthetic route with two consecutive coordination chemistry steps on a solid support affords tris-heteroleptic ruthenium(II) polypyridyl complexes with high purity and in good yields. As an application we report the identification of a nanomolar acetylcholinesterase inhibitor from a small ruthenium complex library synthesized on Lanterns.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / drug effects*
  • Cholinesterase Inhibitors / pharmacology*
  • Combinatorial Chemistry Techniques
  • Drug Evaluation, Preclinical
  • Inhibitory Concentration 50
  • Macromolecular Substances / chemical synthesis*
  • Macromolecular Substances / chemistry
  • Molecular Structure
  • Pyridines / chemistry
  • Ruthenium / chemistry*
  • Small Molecule Libraries
  • Stereoisomerism

Substances

  • Cholinesterase Inhibitors
  • Macromolecular Substances
  • Pyridines
  • Small Molecule Libraries
  • Ruthenium
  • Acetylcholinesterase