Protamine usage following implantation of drug-eluting stents: a word of caution

Catheter Cardiovasc Interv. 2008 Jun 1;71(7):913-4. doi: 10.1002/ccd.21439.

Abstract

The treatment of hemorrhagic complications of percutaneous interventions with protamine is an accepted practice. Concerns exist about the increased thrombo-genicity of drug-eluting stents. We report two cases of acute stent thrombosis following drug-eluting stent implantation related to protamine administration.

Publication types

  • Case Reports

MeSH terms

  • Angioplasty, Balloon, Coronary / adverse effects*
  • Angioplasty, Balloon, Coronary / instrumentation
  • Coronary Angiography
  • Coronary Thrombosis / chemically induced*
  • Coronary Thrombosis / diagnostic imaging
  • Drug-Eluting Stents*
  • Fatal Outcome
  • Hemorrhage / diagnostic imaging
  • Hemorrhage / drug therapy*
  • Hemorrhage / etiology
  • Heparin Antagonists / adverse effects*
  • Humans
  • Protamines / adverse effects*

Substances

  • Heparin Antagonists
  • Protamines