Abstract
Massive pulmonary embolism is an uncommon complication of multiple myeloma treated with thalidomide-dexamethasone regimen. In 2006, multiple myeloma was diagnosed in a 72-year-old man, who received thalidomide-dexamethasone therapy. In January 2007, echocardiography and computerized tomography identified massive pulmonary embolism in the pulmonary arteries and a deep vein thrombus of the right leg. The patient also had an elevated concentration of B-type natriuretic peptide. After heparinization and warfarin therapy, the patient's condition improved. This is the first report of a patient with a rare complication of pulmonary embolism from thalidomide-treated multiple myeloma.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Dexamethasone / administration & dosage
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Dexamethasone / adverse effects
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Humans
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Male
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Multiple Myeloma / blood
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Multiple Myeloma / diagnostic imaging
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Multiple Myeloma / drug therapy*
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Natriuretic Peptide, Brain / blood
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Pulmonary Embolism / blood
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Pulmonary Embolism / chemically induced*
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Pulmonary Embolism / diagnostic imaging
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Radiography
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Thalidomide / administration & dosage
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Thalidomide / adverse effects
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Ultrasonography
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Venous Thrombosis / blood
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Venous Thrombosis / chemically induced
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Venous Thrombosis / diagnostic imaging
Substances
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Natriuretic Peptide, Brain
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Thalidomide
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Dexamethasone