Objective: Interhemisperic lipomas are almost always associated with hypogenesis or agenesis of the corpus callosum. These lesions are stable.
Clinical presentation: We report a case of an interhemispheric lipoma in a 72-year-old man who had undergone myelolipomatous differentiation.
Intervention: Gross total excision of the lesion was performed.
Conclusion: Although extremely uncommon, the possibility of myelomatous change should be considered in the differential diagnosis of an intracranial lipoma if it shows some areas of mixed density.