Inhibition of rat lens aldose reductase by quercetagetin and patuletin

Yan Ke Xue Bao. 1991 Mar;7(1):29-30, 33.

Abstract

In this paper the results of inhibition of the Aldose reductase (AR) activity on Wistar rat lens by Quercetagetin extracted from Tagetes erects Linn and by Patuletin extracted from Tagetes patula Linn are reported. Quercetagetin inhibited AR of the rat lens by 93.9% at 10(-4) M, 76.0% at 10(-5) M and 13.3% at 10(-6) M. Patuletin inhibited AR of the rat lens by 100% at 10(-1) M, 80% at 10(-5) M and 22.7% at 10(-6) M respectively. The results show that these two flavones are lens AR Inhibitors, but further study should be done for the possibility of clinical application.

MeSH terms

  • Aldehyde Reductase / metabolism*
  • Animals
  • Chromones / pharmacology*
  • Drugs, Chinese Herbal / pharmacology*
  • Flavones
  • Lens, Crystalline / enzymology*
  • Rats
  • Rats, Wistar

Substances

  • Chromones
  • Drugs, Chinese Herbal
  • Flavones
  • patuletin
  • Aldehyde Reductase
  • quercetagetin