Abstract
Cancer stem cells (CSCs) are a subpopulation of tumor cells that retain properties of tissue-specific stem cells, including the ability to self-renew. In a recent article in Nature, Malanchi et al. (2008) identified a population of CD34(+) cells in epidermal tumors that require beta-catenin signaling to maintain a CSC phenotype.
MeSH terms
-
Animals
-
Antigens, CD34
-
Hair Follicle / pathology
-
Humans
-
Keratinocytes / pathology
-
Keratinocytes / physiology
-
Mice
-
Neoplasm Transplantation
-
Neoplastic Stem Cells / pathology
-
Neoplastic Stem Cells / physiology*
-
Signal Transduction*
-
Skin Neoplasms / pathology*
-
Skin Neoplasms / physiopathology
-
Tumor Stem Cell Assay
-
beta Catenin / physiology*
Substances
-
Antigens, CD34
-
beta Catenin