Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis

J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6. doi: 10.1080/10286020801966591.

Abstract

During the study of anti-HIV-1 active components of the aqueous extracts of the roots of Salvia yunnanensis, three new derivatives of polyphenols, namely: methyl salvianolate A (2), ethyl salvianolate A (3) and cis-lithospermic acid (5) were isolated along with two known polyphenols, salvianolic acid A (1) and lithospermic acid (4) their structures were elucidated on the basis of NMR and MS spectral analyses. The anti-HIV-1 activities of the 5 polyphenols were tested for the inhibition of P24 antigen in HIV-1 infected MT-4 cell cultures and HIV-1 replicative enzymes in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology
  • Caffeic Acids / chemistry
  • Caffeic Acids / isolation & purification*
  • Caffeic Acids / pharmacology
  • Cell Line
  • Depsides / chemistry
  • Depsides / isolation & purification*
  • Depsides / pharmacology
  • HIV Core Protein p24 / antagonists & inhibitors*
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • Humans
  • Lactates / chemistry
  • Lactates / isolation & purification*
  • Lactates / pharmacology
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / isolation & purification
  • Salvia / chemistry*

Substances

  • Anti-HIV Agents
  • Benzofurans
  • Caffeic Acids
  • Depsides
  • HIV Core Protein p24
  • Lactates
  • Plant Extracts
  • Reverse Transcriptase Inhibitors
  • lithospermic acid
  • salvianolic acid A
  • HIV Reverse Transcriptase