IRAK-4 inhibitors. Part 1: a series of amides

George M Buckley; Lewis Gowers; Alicia Perez Higueruelo; Kerry Jenkins; Stephen R Mack; Trevor Morgan; David M Parry; William R Pitt; Oliver Rausch; Marianna D Richard; Verity Sabin; Joanne L Fraser

doi:10.1016/j.bmcl.2008.04.058

IRAK-4 inhibitors. Part 1: a series of amides

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. doi: 10.1016/j.bmcl.2008.04.058. Epub 2008 Apr 26.

Authors

George M Buckley¹, Lewis Gowers, Alicia Perez Higueruelo, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin, Joanne L Fraser

Affiliation

¹ UCB, Department of Medicinal Chemistry, Granta Park, Great Abington, Cambridge, CB21 6GS, UK.

PMID: 18474425
DOI: 10.1016/j.bmcl.2008.04.058

Abstract

The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.

MeSH terms

Amides / chemical synthesis*
Amides / chemistry
Amides / pharmacology*
Drug Design
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
Interleukin-1 Receptor-Associated Kinases / antagonists & inhibitors*
Models, Biological*
Molecular Structure
Pyridines / chemical synthesis*
Pyridines / chemistry
Pyridines / pharmacology*
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Structure-Activity Relationship

Substances

Amides
Enzyme Inhibitors
Pyridines
Small Molecule Libraries
Interleukin-1 Receptor-Associated Kinases