Salt restriction in kidney disease--a missed therapeutic opportunity?

Pediatr Nephrol. 2009 Jan;24(1):9-17. doi: 10.1007/s00467-008-0856-4. Epub 2008 Jun 6.

Abstract

The importance of salt restriction in the treatment of patients with renal disease has remained highly controversial. In the following we marshal the current evidence that salt plays a definite role in the genesis of hypertension and target organ damage, point to practical problems of salt restriction, and report on novel pathomechanisms of how salt affects blood pressure and causes target organ damage.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Animals
  • Blood Pressure / drug effects
  • Cardiac Glycosides / genetics
  • Cardiac Glycosides / metabolism
  • Child
  • Chronic Disease
  • Controlled Clinical Trials as Topic
  • Diet, Sodium-Restricted*
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation
  • Humans
  • Hypertension / chemically induced
  • Hypertension / physiopathology
  • Kidney / drug effects
  • Kidney / physiopathology
  • Kidney Diseases / diet therapy*
  • Kidney Diseases / metabolism
  • Kidney Diseases / physiopathology
  • Male
  • Sodium Chloride, Dietary / administration & dosage*
  • Sodium Chloride, Dietary / adverse effects
  • Sodium Chloride, Dietary / metabolism

Substances

  • Cardiac Glycosides
  • Sodium Chloride, Dietary