Abstract
Five new cembrane-type diterpenoids with a trans-fused alpha-methylene-gamma-lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Female
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Humans
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Lamiaceae / chemistry*
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Molecular Structure
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Plants, Medicinal / chemistry*
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology*
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Taiwan
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Thrombin / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Glucosides
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Platelet Aggregation Inhibitors
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Thrombin