Lewis antigen expression by Helicobacter pylori strains colonizing different regions of the stomach of individual patients

J Clin Microbiol. 2008 Aug;46(8):2783-5. doi: 10.1128/JCM.02370-07. Epub 2008 Jun 11.

Abstract

The diversity in the expression of Lewis antigens (Le) of 226 single colonies of Helicobacter pylori isolated from four regions of the stomach of eight adults is shown. Le(y) was expressed more in strains colonizing antrum than in strains colonizing fundus, whereas Le(x) was more common in fundus strains. cagA(+) strains were more associated with Le-negative strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, Bacterial / biosynthesis*
  • Antigens, Bacterial / genetics
  • Bacterial Proteins / genetics
  • Female
  • Gastric Fundus / microbiology*
  • Helicobacter pylori / immunology*
  • Helicobacter pylori / isolation & purification
  • Humans
  • Lewis Blood Group Antigens / biosynthesis*
  • Male
  • Middle Aged
  • Pyloric Antrum / microbiology*

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • Lewis Blood Group Antigens
  • cagA protein, Helicobacter pylori