Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis

Chembiochem. 2008 Jul 21;9(11):1716-20. doi: 10.1002/cbic.200800210.

Abstract

Bacillus anthracis vaccine candidate: Sera of rabbits exposed to live and irradiated-killed spores of B. anthracis Sterne 34F2 or immunized with B. anthracis polysaccharide conjugated to KLH elicited antibodies that recognize isolated polysaccharide and two synthetic trisaccharides providing a proof-of-concept step in the development of vegetative and spore-specific reagents for detection and targeting of non-protein structures of B. anthracis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anthrax Vaccines / chemical synthesis*
  • Anthrax Vaccines / immunology*
  • Anthrax Vaccines / metabolism
  • Antibodies / immunology
  • Bacillus anthracis / cytology*
  • Bacillus anthracis / immunology*
  • Bacillus anthracis / metabolism
  • Cattle
  • Cell Wall / chemistry*
  • Cell Wall / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Hemocyanins / metabolism
  • Oligosaccharides / chemical synthesis*
  • Oligosaccharides / immunology*
  • Oligosaccharides / metabolism
  • Rabbits
  • Spores, Bacterial / immunology
  • Spores, Bacterial / metabolism

Substances

  • Anthrax Vaccines
  • Antibodies
  • Oligosaccharides
  • Hemocyanins