What grid cells convey about rat location

J Neurosci. 2008 Jul 2;28(27):6858-71. doi: 10.1523/JNEUROSCI.5684-07.2008.

Abstract

We characterize the relationship between the simultaneously recorded quantities of rodent grid cell firing and the position of the rat. The formalization reveals various properties of grid cell activity when considered as a neural code for representing and updating estimates of the rat's location. We show that, although the spatially periodic response of grid cells appears wasteful, the code is fully combinatorial in capacity. The resulting range for unambiguous position representation is vastly greater than the approximately 1-10 m periods of individual lattices, allowing for unique high-resolution position specification over the behavioral foraging ranges of rats, with excess capacity that could be used for error correction. Next, we show that the merits of the grid cell code for position representation extend well beyond capacity and include arithmetic properties that facilitate position updating. We conclude by considering the numerous implications, for downstream readouts and experimental tests, of the properties of the grid cell code.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Computer Simulation
  • Entorhinal Cortex / anatomy & histology
  • Entorhinal Cortex / physiology*
  • Hippocampus / anatomy & histology
  • Hippocampus / physiology*
  • Mental Processes / physiology
  • Nerve Net / anatomy & histology
  • Nerve Net / physiology*
  • Neural Networks, Computer
  • Neural Pathways / anatomy & histology
  • Neural Pathways / physiology
  • Neurons / physiology*
  • Orientation / physiology*
  • Rats
  • Space Perception / physiology*
  • Synaptic Transmission / physiology