[Prevalence and comorbidity of neuropsychiatric symptoms in Alzheimer's disease]

Actas Esp Psiquiatr. 2008 Sep-Oct;36(5):265-70.
[Article in Spanish]

Abstract

Introduction: The objective of this study is to describe the frequency and severity of behavioral and psychological symptoms (BPS) in a group of 125 patients diagnosed of Alzheimer's disease (AD) (DSM-IV-TR and NINCDSADRDA criteria).

Methods: The evaluation of the BPS was carried out using the Neuropsychiatric Inventory (NPI; Cummings et al., 1994). The sociodemographic and personal background data of the patients were gathered and the dementia stage was established with the Global Deterioration Scale (GDS Reisberg, 1982).

Results: A total of 122 patients (98%) presented BPS, with an average of five symptoms per patient. Frequency of presentation was the following: apathy (75%), irritability (66%), depression (60%), agitation (55%), anxiety (54%), aberrant motor activity (47%), delirium (38%), sleeping disorders (36%), disinhibition (29%), eating disorders (28%), hallucinations (20%) and euphoria (4%).

Conclusions: These results show the high incidence of BPS in AD patients and point to the necessity and importance of treating these disorders appropriately.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / epidemiology*
  • Comorbidity
  • Female
  • Humans
  • Male
  • Mental Disorders / epidemiology*
  • Middle Aged
  • Neuropsychological Tests
  • Prevalence