Lack of multiple copies of pfmdr1 gene in Papua New Guinea

Trans R Soc Trop Med Hyg. 2008 Nov;102(11):1151-3. doi: 10.1016/j.trstmh.2008.05.017. Epub 2008 Jul 2.

Abstract

We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / therapeutic use*
  • Artemisinins / therapeutic use
  • Artesunate
  • Drug Resistance / genetics
  • Genes, MDR / genetics
  • Genotype
  • Humans
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / genetics*
  • Mefloquine / therapeutic use
  • Multidrug Resistance-Associated Proteins / genetics*
  • Papua New Guinea
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / genetics*
  • Polymorphism, Genetic

Substances

  • Antimalarials
  • Artemisinins
  • Mdr1 protein, Plasmodium falciparum
  • Multidrug Resistance-Associated Proteins
  • Artesunate
  • Mefloquine