Traditional and alternative designs for pulmonary arterial hypertension trials

Proc Am Thorac Soc. 2008 Jul 15;5(5):610-6. doi: 10.1513/pats.200803-024SK.

Abstract

This article elaborates on the phases of drug development and trial design for pulmonary arterial hypertension, emphasizing the need for learning trials to assess efficacy signals before confirming trials. In this new era in pulmonary arterial hypertension, we need to reconsider innovative trial designs to maximize efficiency and pursue agents with the greatest potential for cure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use*
  • Clinical Trials as Topic / methods*
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Reproducibility of Results

Substances

  • Antihypertensive Agents