Substance use and misuse are well-known public health issues. Indeed, more than half of the adolescents involved with substances has seen a general practitioner at least once in a recent period. Early identification of substance use and misuse among teenagers is a major issue, in which general practitioners could play a larger role. The DEPART program, based in the canton of Vaud, offers specific support to help general practitioners identify substance use and misuse early on and, when necessary, provide specific care in the form of motivational interviewing.