The diagnostic of sarcoidosis is done when clinical and radiological usual signs are present with nonnecrotizing granuloma and in the absence of any other granulomatous disease. However, if associated with usual manifestations of sarcoidosis and if published similar case reports are available, diagnostic is not excluded by atypical clinical or radiological facts. Chest thin-section hight-resolution computed tomographic scan is very useful to obvious typical findings when chest-X-ray looks unusual. In some cases, achievement of granuloma can be delayed if sarcoidosis does not require any drug. Besides, difficulties exist regarding alternative diagnosis, particularly tuberculosis for patients from endemic countries. Lastly, clinical course manifestations rise to know the discriminate between sarcoidosis, treatment side-effects and others sarcoidosis-associated diseases.