Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis

G Mamutse; J Woolmore; E Pye; J Partridge; M Boggild; C Young; A Fryer; P R Hoban; N Rukin; J Alldersea; R C Strange; C P Hawkins

doi:10.1177/1352458508094643

Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis

Mult Scler. 2008 Nov;14(9):1280-3. doi: 10.1177/1352458508094643. Epub 2008 Jul 24.

Authors

G Mamutse¹, J Woolmore, E Pye, J Partridge, M Boggild, C Young, A Fryer, P R Hoban, N Rukin, J Alldersea, R C Strange, C P Hawkins

Affiliation

¹ Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK.

PMID: 18653739
DOI: 10.1177/1352458508094643

Abstract

Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G(1229), C/G(3444), G/A(3944), CC(20965), CC(30056), F/f(30875), C/T(48200), T/t(65013)) with outcome or disability. ff(30875) frequency was lower in cases with EDSS > or = 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20-0.70). The association of ff(30875) with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14-1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16-0.73).

MeSH terms

Adult
Disability Evaluation*
Female
Genetic Predisposition to Disease / epidemiology
Haplotypes
Humans
Logistic Models
Male
Multiple Sclerosis / epidemiology
Multiple Sclerosis / genetics*
Multiple Sclerosis / physiopathology
Polymorphism, Single Nucleotide*
Receptors, Calcitriol / genetics*
Risk Factors
Ultraviolet Rays*
Young Adult

Substances

Receptors, Calcitriol