Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

Elizabeth S Sattely; Michael A Fischbach; Christopher T Walsh

doi:10.1039/b801747f

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

Nat Prod Rep. 2008 Aug;25(4):757-93. doi: 10.1039/b801747f. Epub 2008 May 23.

Authors

Elizabeth S Sattely¹, Michael A Fischbach, Christopher T Walsh

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

PMID: 18663394
DOI: 10.1039/b801747f

Abstract

This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / biosynthesis*
Genome, Bacterial*
Macrolides / metabolism*
Molecular Structure
Peptide Synthases* / genetics
Peptide Synthases* / metabolism
Peptides / genetics
Peptides / metabolism*

Substances

Anti-Bacterial Agents
Macrolides
Peptides
Peptide Synthases