Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp

J Antibiot (Tokyo). 2008 Jun;61(6):387-93. doi: 10.1038/ja.2008.54.

Abstract

A novel cyclic peptide antibiotic, pargamicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated ML1-hF4, was identified as a member of the genus Amycolatopsis. Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. Pargamicin A showed potent antibacterial activity against Staphylococcus aureus strains including MRSA and Enterococcus faecalis/faecium strains including VRE.

MeSH terms

  • Actinomycetales / classification
  • Actinomycetales / growth & development
  • Actinomycetales / metabolism*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Antimicrobial Cationic Peptides / biosynthesis
  • Antimicrobial Cationic Peptides / chemistry
  • Antimicrobial Cationic Peptides / isolation & purification*
  • Antimicrobial Cationic Peptides / pharmacology*
  • Culture Media, Conditioned / metabolism
  • Enterococcus faecalis / drug effects
  • Enterococcus faecium / drug effects
  • Fermentation
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / biosynthesis
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology*
  • Pyridazines / analysis
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Culture Media, Conditioned
  • Peptides, Cyclic
  • Pyridazines
  • pargamicin A
  • piperazic acid