Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma

AIDS. 2008 Aug 20;22(13):1677-9. doi: 10.1097/QAD.0b013e32830abdc8.

Abstract

Five percent of 145 HIV-1 infected men enrolled in an assisted reproductive technology (ART) program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment. This result justifies measuring HIV-1 RNA in semen before the ART process and suggests that a residual risk of transmission has to be mentioned to the patients who would like to have unprotected sexual intercourse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Retroviral Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • HIV Infections / drug therapy
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Humans
  • Infectious Disease Transmission, Vertical
  • Male
  • Middle Aged
  • Plasma / virology
  • RNA, Viral / analysis*
  • RNA, Viral / blood
  • Reproductive Techniques, Assisted
  • Risk
  • Semen / virology*
  • Viral Load / methods

Substances

  • Anti-Retroviral Agents
  • RNA, Viral