A tissue cage model was adapted and utilized for examination of the inflammatory-reparative response in the chicken. The model involved insertion of a polyethylene cage, soaked in the irritant, into the previously prepared subcutaneous pouch. Using this model the cellular events in the fibrovascular granulation tissue in response to turpentine, concanavalin-A and Escherichia coli endotoxin were studied. It was concluded that the tissue cage model worked well in the chicken and that it can be useful in studies relating to the inflammatory-reparative response.