Abstract
Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
MeSH terms
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Animals
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Humans
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JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors*
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JNK Mitogen-Activated Protein Kinases / metabolism
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacology*
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Pyridines / chemistry
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Pyridines / pharmacology
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Quinolines / chemistry
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Quinolines / pharmacology
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Structure-Activity Relationship
Substances
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Protein Kinase Inhibitors
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Pyridines
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Quinolines
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quinoline
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JNK Mitogen-Activated Protein Kinases
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pyridine