Abstract
Four new cyclopeptides, cyclomontanins A-D (1- 4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annona / embryology*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cell Line
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Seeds / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Peptides, Cyclic