Abstract
Our population-based study of the Mycobacterium tuberculosis Beijing family examined the frequency of occurrence of each sublineage of this family, classified by using 10 synonymous single-nucleotide polymorphisms. The results revealed the overabundance of two evolutionary sublineages in a population of multidrug-resistant and extensively drug-resistant tuberculosis bacteria.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Bacterial Typing Techniques
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Drug Resistance, Multiple, Bacterial
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Female
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Humans
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Male
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Middle Aged
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Molecular Epidemiology
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Mutation
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification
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Polymorphism, Single Nucleotide
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Species Specificity
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Tuberculosis, Pulmonary / drug therapy
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Tuberculosis, Pulmonary / epidemiology
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Tuberculosis, Pulmonary / microbiology