Infantile-onset cutaneous T-cell lymphoma

Br J Dermatol. 2008 Dec;159(6):1338-41. doi: 10.1111/j.1365-2133.2008.08794.x. Epub 2008 Aug 19.

Abstract

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is mainly a disease of the elderly.

Objectives: To review paediatric CTCL cases reported in the literature, with a focus on the time between onset of symptoms and establishment of a correct diagnosis.

Methods: A review of the literature was carried out and a case reported.

Results: A total of 254 cases of CTCL have been reported in children aged<16 years, 13 cases (<1% of all reported cases) in children below the age of 2 years, and only seven cases (including ours) during the first year of life. CTCL was most prevalent in children aged 10-12 years. The delay between age of onset and establishment of diagnosis was largest in the youngest age group (0-3 years), and declined steadily thereafter, thus reflecting the increasing likelihood that CTCL is considered in the differential diagnosis of skin disorders with increasing age of the patient.

Conclusions: The diagnosis of CTCL is frequently delayed in young children. It needs to be considered in chronic 'eczematous' skin lesions irrespective of the patient's age, and including infants.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antimetabolites, Antineoplastic / therapeutic use
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Humans
  • Infant
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / immunology
  • Lymphoma, T-Cell, Cutaneous / therapy
  • Male
  • Methotrexate / therapeutic use
  • Mycosis Fungoides / diagnosis*
  • Mycosis Fungoides / immunology
  • Mycosis Fungoides / therapy
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / immunology
  • Skin Neoplasms / therapy
  • Treatment Outcome
  • Ultraviolet Therapy

Substances

  • Antimetabolites, Antineoplastic
  • Methotrexate