Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole

Uwe Wollina; Gesina Hansel; Irina Vennewald; Jacqueline Schönlebe; Kathrin Tintelnot; Michael Seibold; Thomas Kittner

doi:10.1111/j.1610-0387.2008.06863.x

Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole

J Dtsch Dermatol Ges. 2009 Jan;7(1):46-9. doi: 10.1111/j.1610-0387.2008.06863.x. Epub 2008 Aug 26.

[Article in English, German]

Authors

Uwe Wollina¹, Gesina Hansel, Irina Vennewald, Jacqueline Schönlebe, Kathrin Tintelnot, Michael Seibold, Thomas Kittner

Affiliation

¹ Department of Dermatology and Allergy, Dresden-Friedrichstadt Hospital, Academic Teaching Hospital of the Technical University, Dresden Germany. wollina-uw@khdf.de

PMID: 18759738
DOI: 10.1111/j.1610-0387.2008.06863.x

Abstract

A 52-year-old woman with pulmonary sarcoidosis on immunosuppressive therapy developed pulmonary infiltrates and cutaneous granulomatous abscesses after a trip to the USA in April 2005. A hyphomycete was identified, further characterized by a gene probe as Coccidioides spp. and then definitively identified as Coccidioides posadasii by polymerase chain reaction and sequencing. Antibodies towards Coccidioides spp. were detected. The infection was successfully treated with posaconazole (Noxafil), 2 x 400 mg/d.

Publication types

Case Reports

MeSH terms

Antifungal Agents / administration & dosage*
Coccidioidomycosis / diagnosis*
Coccidioidomycosis / drug therapy
Coccidioidomycosis / prevention & control*
Dermatomycoses / diagnosis*
Dermatomycoses / drug therapy
Dermatomycoses / prevention & control*
Humans
In Vitro Techniques
Middle Aged
Secondary Prevention
Treatment Outcome
Triazoles / administration & dosage*

Substances

Antifungal Agents
Triazoles
posaconazole