A large observational study of cardiovascular outcomes associated with atorvastatin or simvastatin therapy in diabetic patients without prior cardiovascular disease

Joanne M Foody; Amie T Joyce; Barrett W Jeffers; Larry Z Liu; Joshua S Benner

doi:10.1016/j.diabres.2008.07.019

A large observational study of cardiovascular outcomes associated with atorvastatin or simvastatin therapy in diabetic patients without prior cardiovascular disease

Diabetes Res Clin Pract. 2008 Oct;82(1):e13-5. doi: 10.1016/j.diabres.2008.07.019. Epub 2008 Sep 6.

Authors

Joanne M Foody¹, Amie T Joyce, Barrett W Jeffers, Larry Z Liu, Joshua S Benner

Affiliation

¹ Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02130, USA.

PMID: 18774618
DOI: 10.1016/j.diabres.2008.07.019

Abstract

Analysis of claims data from 46,076 diabetic patients without cardiovascular disease initiating atorvastatin or simvastatin therapy suggested that, after adjusting for demographic and clinical confounders, use of atorvastatin was associated with fewer cardiovascular events versus simvastatin at doses of similar potency (HR 0.88, 95% CI 0.80-0.97, P=0.01).

MeSH terms

Adult
Aged
Anticholesteremic Agents / adverse effects
Anticholesteremic Agents / therapeutic use
Atorvastatin
Cardiovascular Diseases / chemically induced*
Cardiovascular Diseases / epidemiology
Diabetes Mellitus / drug therapy*
Health Maintenance Organizations / statistics & numerical data
Heptanoic Acids / adverse effects*
Heptanoic Acids / therapeutic use
Humans
Preferred Provider Organizations / statistics & numerical data
Pyrroles / adverse effects*
Pyrroles / therapeutic use
Simvastatin / adverse effects*
Simvastatin / therapeutic use
Treatment Outcome
United States / epidemiology

Substances

Anticholesteremic Agents
Heptanoic Acids
Pyrroles
Atorvastatin
Simvastatin