Properties of superparamagnetic iron oxide nanoparticles assembled on nucleic acids

Kazuo Tanaka; Narufumi Kitamura; Yoshiki Chujo

doi:10.1093/nass/nrn350

Properties of superparamagnetic iron oxide nanoparticles assembled on nucleic acids

Nucleic Acids Symp Ser (Oxf). 2008:(52):693-4. doi: 10.1093/nass/nrn350.

Authors

Kazuo Tanaka¹, Narufumi Kitamura, Yoshiki Chujo

Affiliation

¹ Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Nishikyoku, Kyoto 615-8510, Japan.

PMID: 18776569
DOI: 10.1093/nass/nrn350

Abstract

We report the direct modification of SPIOs with a biomolecule, and the sequence-specific assembly of the modified SPIOs was achieved with the aptamer-small molecule interaction. In addition, the transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.

MeSH terms

Aptamers, Nucleotide / chemistry*
DNA / chemistry*
Ferric Compounds / chemistry*
Hemin / chemistry
Magnetic Resonance Imaging
Metal Nanoparticles / chemistry*
Nuclear Magnetic Resonance, Biomolecular

Substances

Aptamers, Nucleotide
Ferric Compounds
ferric oxide
Hemin
DNA