Development of a rapid method to determine phenolic and other polar compounds in walnut by capillary electrophoresis-electrospray ionization time-of-flight mass spectrometry

J Chromatogr A. 2008 Oct 31;1209(1-2):238-45. doi: 10.1016/j.chroma.2008.08.117. Epub 2008 Sep 7.

Abstract

The aim of this work was to develop a capillary electrophoresis-mass spectrometry (CE-MS) method to identify and quantify phenolic and other related polar compounds in walnut samples. The extraction capacity of several solvent mixtures of phenolic compounds from walnut by conventional solid-liquid extractions was tested, and CE and electrospray ionization MS parameters were optimized. The finalized procedure is able to determine many well-known phenolic compounds present in walnuts and provide relevant information about the presence of minor polar compounds. A new compound in walnut ((2E,4E)-8-hydroxy-2,7-dimethyl-2,4-decadiene-1,10-dioic acid 6-O-beta-d-glucopiranosyl ester, [M-H](-) 403.161m/z) with a structure similar to glansreginins was also identified. Phenolic compounds correspond to 14-28% of total polar compounds quantified. Aglycone and glycosylated ellagic acid represent the principal components and account for 64-75% of total phenols in walnuts. However, the sum of glansreginins A, B and (2E,4E)-8-hydroxy-2,7-dimethyl-2,4-decadiene-1,10-dioic acid 6'-O-beta-d-glucopiranosyl ester was in the range of 72-86% of total quantified compounds. In addition, this is the first time that separation by CE with detection by electrospray ionization time-of-flight MS has been applied to the analysis of phenolic and other polar compounds in walnut samples, providing results in less than 15min.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrophoresis, Capillary / methods*
  • Juglans / chemistry*
  • Phenols / analysis*
  • Reproducibility of Results
  • Spectrometry, Mass, Electrospray Ionization / methods*

Substances

  • Phenols