A Wnt-fall for gene regulation: repression

Sci Signal. 2008 Sep 30;1(39):pe43. doi: 10.1126/scisignal.139pe43.

Abstract

A major endpoint of the canonical Wnt signaling pathway is a change in the transcription of target genes. The transcription factors lymphoid enhancer factor (LEF) and T cell factor (TCF) serve as the main gatekeepers of these changes by selecting genes to be targeted by the transcriptional coregulator beta-catenin and by defining how target gene expression will be altered. Most research has focused on LEF/TCF:beta-catenin-mediated activation of transcription, but there have been some reports that suggest that this complex also directly represses transcription. A recent study uncovered a new mode of repression of Wnt target genes in which recognition of a novel DNA element by TCF specifies that beta-catenin acts as a transcriptional repressor.

MeSH terms

  • Animals
  • Drosophila / metabolism
  • Drosophila Proteins / physiology*
  • Gene Expression Regulation
  • Protein Binding
  • Signal Transduction
  • TCF Transcription Factors / physiology*
  • Wnt Proteins / physiology*
  • beta Catenin / physiology

Substances

  • Drosophila Proteins
  • TCF Transcription Factors
  • Wnt Proteins
  • beta Catenin