Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5463-5. doi: 10.1016/j.bmcl.2008.09.035. Epub 2008 Sep 11.

Abstract

We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Biotin / chemistry
  • Chemistry, Pharmaceutical / methods
  • Contrast Media / chemistry
  • Contrast Media / pharmacology*
  • DNA / chemistry
  • Drug Design
  • Ferric Compounds / chemistry*
  • Hemin / chemistry
  • Hydrogen-Ion Concentration
  • Ligands
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Time Factors

Substances

  • Aptamers, Nucleotide
  • Contrast Media
  • Ferric Compounds
  • Ligands
  • ferric oxide
  • Biotin
  • Hemin
  • DNA