Design, synthesis and in vitro microbiological evaluation of 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones--a new series of 'tailor-made' compounds

J Enzyme Inhib Med Chem. 2009 Apr;24(2):406-12. doi: 10.1080/14756360802188099.

Abstract

Some novel 'tailor-made' compounds, 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones 23-27 have been studied for their in vitro antibacterial activity against Staphylococcus aureus, beta-Heamolytic streptococcus, Vibreo cholerae, Salmonella typhii, Shigella felxneri, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and anti-fungal activity against Aspergillus flavus, Mucor, Rhizopus and Microsporum gypsuem. Compounds 24 and 25 exerted potent antibacterial activity against S. aureus, beta-H. streptococcus, E. coli and P. aeruginosa whereas all compounds 23-27 exerted strong in vitro antifungal activity against A. flavus, Mucor and Rhizopus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / pharmacology
  • Microbial Sensitivity Tests
  • Microbial Viability
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / metabolism
  • Thiones / chemical synthesis*
  • Thiones / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Thiones