Abstract
Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.
MeSH terms
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Animals
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Cell Line
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Dogs
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Epithelium / physiology
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Homeodomain Proteins / physiology
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Humans
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Mesoderm / physiology
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MicroRNAs / physiology*
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Neoplasm Metastasis / physiopathology
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Neoplasms / etiology*
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Nerve Tissue Proteins / physiology
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RNA-Binding Proteins / physiology
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Transcription Factors / physiology
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Zinc Finger E-box-Binding Homeobox 1
Substances
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GEMIN2 protein, human
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Homeodomain Proteins
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MicroRNAs
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Nerve Tissue Proteins
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RNA-Binding Proteins
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Transcription Factors
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ZEB1 protein, human
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Zinc Finger E-box-Binding Homeobox 1