IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative

Nat Immunol. 2008 Nov;9(11):1210-2. doi: 10.1038/ni1108-1210.

Abstract

Interferon-γ exerts many effects on the immune system. A new report shows that it induces both autophagy and Irgm1, a GTPase that protects activated CD4+ T cells from executing autophagy.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Autophagy* / genetics
  • CD4-Positive T-Lymphocytes / enzymology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Proliferation
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / physiology*
  • Interferon-gamma / immunology*
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Th1 Cells / immunology

Substances

  • Ifi1 protein, mouse
  • Interferon-gamma
  • GTP-Binding Proteins