Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice

Reprod Toxicol. 2008 Nov-Dec;26(3-4):231-8. doi: 10.1016/j.reprotox.2008.09.007. Epub 2008 Oct 5.

Abstract

The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgen Antagonists / toxicity*
  • Animals
  • Body Weight / drug effects
  • Female
  • Fetus / drug effects*
  • Fungicides, Industrial / toxicity*
  • Genitalia, Male / drug effects*
  • Genitalia, Male / embryology
  • Male
  • Mice
  • Mice, Inbred ICR
  • Organ Size / drug effects
  • Oxazoles / toxicity*
  • Pregnancy
  • Reverse Transcriptase Polymerase Chain Reaction
  • Spermatogenesis / drug effects*
  • Testis / drug effects
  • Testis / metabolism
  • Ubiquitin / metabolism

Substances

  • Androgen Antagonists
  • Fungicides, Industrial
  • Oxazoles
  • Ubiquitin
  • vinclozolin