CMV and the art of memory maintenance

Immunity. 2008 Oct 17;29(4):520-2. doi: 10.1016/j.immuni.2008.09.008.

Abstract

The CD8(+) T cell responses to CMV gradually increase in magnitude over time-so-called memory "inflation." In this issue of Immunity, Snyder et al. (2008) examine the dynamics of memory inflation and demonstrate continuous turnover of inflating T cells, drawing on both memory cells and naive cells to replace them.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, CD / immunology
  • Antigens, CD / metabolism*
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / immunology*
  • Cytomegalovirus Infections / virology
  • Herpesviridae Infections / immunology
  • Humans
  • Immunologic Memory*
  • Mice
  • Muromegalovirus / immunology*

Substances

  • Antigens, CD
  • Cytokines