The differences of platelet response to snake venoms: a comparative study of children and adults

Toxicon. 2008 Dec 15;52(8):960-3. doi: 10.1016/j.toxicon.2008.09.007. Epub 2008 Oct 10.

Abstract

Platelets play a vital role in the coagulation, yet the potential for differences in platelet function, between adults and children, remains underexplored. This is despite the age-related variation in haemostatic proteins, that is encompassed by the term Developmental Haemostasis. Hemotoxins found in the venoms of Australian snakes mimic human blood coagulation factors. The effects of Australian snake venoms on platelets, as well as the possible differential response in adults and children were subject of this study.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Animals
  • Child
  • Child, Preschool
  • Elapid Venoms / pharmacology*
  • Elapidae*
  • Humans
  • Infant
  • Platelet Aggregation / drug effects*

Substances

  • Elapid Venoms