In May 2008, 800 delegates from 64 countries met at the International Symposium on HIV and Emerging Infectious Diseases in France to discuss a list of hot topics in HIV and hepatitis viruses. This article summarizes the statements obtained from these discussions around a list of 10 of these topics: (a) antiretroviral treatment for naïve patients; (b) use of integrase inhibitors; (c) antiretrovirals in development; (d) management of lipid abnormalities; (e) hepatotoxicity of antiretroviral therapy; (f) management of hepatitis B in HIV patients; (g) management of acute hepatitis C in HIV patients; (h) outcome of HIV-HCV co-infected patients; (i) preexposure prophylaxis in HIV infection; and (j) the long road to a preventive HIV vaccine. For each topic, we reported the main data presented by speakers and summarized the results of the subsequent discussions.