Abstract
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Cell Line
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Cell Movement / drug effects
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Cell Proliferation / drug effects
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Endothelial Cells / cytology
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Endothelial Cells / drug effects
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Estrone / analogs & derivatives
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Humans
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Mice
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Neuropeptides / chemical synthesis*
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Neuropeptides / chemistry
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Neuropeptides / pharmacology*
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Vascular Endothelial Growth Factor A / pharmacology
Substances
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Angiogenesis Inhibitors
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Neuropeptides
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Vascular Endothelial Growth Factor A
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cortistatin
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Estrone