Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones

J Enzyme Inhib Med Chem. 2009 Apr;24(2):447-52. doi: 10.1080/14756360802188511.

Abstract

A new series of 3-(1,2,4-triazol-3-yl)-4-thiazolidinone derivatives has been synthesized by the reaction of Schiff bases of 3-amino-1,2,4-triazoles with mercaptoacetic acid and 2-mercaptopropionic acid. Their antibacterial and antifungal activities were evaluated against S. aureus, S. epidermidis, C. albicans and C. glabrata.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology
  • Microbial Sensitivity Tests
  • Schiff Bases / chemistry
  • Sulfhydryl Compounds / chemistry
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology
  • Thioglycolates / chemistry
  • Triazoles / chemical synthesis*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Schiff Bases
  • Sulfhydryl Compounds
  • Thiazoles
  • Thioglycolates
  • Triazoles
  • 2-mercaptoacetate
  • thiolactic acid