Abstract
Adipose tissue mass can expand throughout adult life. Therefore, proliferative adipocyte precursor cells must stand at the ready to respond to increased demand for energy storage. Recent provocative studies have identified discrete immature cell populations from which brown and white adipocytes are derived. This work not only brings fundamental insight into adipose tissue formation but also provides new tools to study how adipogenesis is regulated in pathological conditions such as obesity and diabetes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipocytes / cytology*
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Adipogenesis*
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Adipose Tissue, Brown / cytology*
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Adipose Tissue, Brown / growth & development
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Adipose Tissue, Brown / metabolism
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Adipose Tissue, White / cytology*
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Adipose Tissue, White / growth & development
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Adipose Tissue, White / metabolism
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Animals
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CD24 Antigen / metabolism
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Mice
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Mice, Transgenic
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PPAR gamma / genetics
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PPAR gamma / metabolism
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Stem Cells / cytology
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Stem Cells / physiology*
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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CD24 Antigen
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PPAR gamma
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Tg(AZIP-F)1Vsn protein, mouse
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Transcription Factors