Chemical structure of the somatic antigen isolated from Salmonella Abortusequi (O4)

J Pharm Biomed Anal. 2009 Nov 1;50(4):679-82. doi: 10.1016/j.jpba.2008.10.013. Epub 2008 Oct 22.

Abstract

A neutral O-specific polysaccharide was obtained by mild acid hydrolysis of the lipopolysaccharide (LPS) of Salmonella Abortusequi O4 bacterium (previously serogroup B). As determined by compositional analyses and NMR spectroscopy, the O-polysaccharide consists of four or five residues in the repeating subunit. The assigned structures are: alpha-Abep -->2)-alpha-D-Manp-(1-->4)-alpha-L-Rhap-(1-->3)-alpha-D-Galp-(1--> and alpha-Abep alpha-D-Glcp -->2)-alpha-D-Manp-(1-->4)-alpha-L-Rhap-(1-->3)-alpha-D-Galp-(1-->. A distribution of the repeating units in O-chain was analysed by Western blotting with anti O12 serum and MS spectrometry of oligosaccharides obtained from partial hydrolysis of polysaccharide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Hydrolysis
  • Lipopolysaccharides / chemistry
  • Magnetic Resonance Spectroscopy / methods*
  • Mass Spectrometry / methods
  • O Antigens / chemistry*
  • Salmonella / immunology*

Substances

  • Lipopolysaccharides
  • O Antigens